Frank Tacke
Spokesperson · Charité Berlin
Every third adult lives with a fatty liver.
Together, we’re working to change what that means.
We are 18 research teams in Berlin and Dresden studying how metabolic dysfunction-associated steatotic liver disease begins, progresses — and how it can be treated.
-
From healthy liver to fibrosis: the stages of MASLD we investigate.
-
How our 18 projects connect across research areas A, B and Z.
-
Our teams at Charité Berlin and TU Dresden.
Achieving more together
No single lab can decode a disease that connects metabolism, immunity and genetics. That's why hepatologists, immunologists, geneticists and data scientists work as one consortium.
- research projects
- 18
- sites — Berlin & Dresden
- 2
- principal investigators
- 30+
- years of funding, 2025–2029
- 4
What we study
Follow the disease from the first injured liver cell to scar tissue — our two research areas cover the full arc.
-
A
How injury begins
Genes, diet, gut bacteria and fat tissue: seven projects trace the signals that push liver cells from healthy to harmed.
Metabolic injury -
B
How it turns harmful
Nine projects follow the immune cells that transform a fatty liver into an inflamed, scarred one.
Inflammation & fibrosis -
Z
What carries us
A shared patient cohort, multi-omics technologies, training for young scientists and central coordination.
Central projects
The people behind the science
More than 30 principal investigators and a growing community of doctoral researchers make up the CRC/TR 412 — clinicians and scientists who see the disease from the bedside and the bench.
Meet our members
-
-
Jochen Hampe
Deputy spokesperson · TU Dresden
-
Andrej Shevchenko
MPI-CBG Dresden
-
Meritxell Huch
MPI-CBG Dresden
-
Michael Sieweke
CRTD · TU Dresden
-
Chiara Romagnani
Charité Berlin & DRFZ
-
Linda Hammerich
Hepatology · Charité Berlin
-
Sofia Forslund
ECRC · Charité & MDC Berlin
-
Moritz Peiseler
Hepatology · Charité Berlin
-
Maria Fedorova
Lipid Research · TU Dresden
Starting your science career?
Our integrated research training group offers joint supervision in Berlin and Dresden, methods workshops and a clinician-scientist track.
Join the iRTGLiving with a fatty liver?
Find out what MASLD means, how our research helps you, and how you can take part in clinical studies.
Information for patients